What is Noopept?

Bottle of Noopept powder

Noopept is the common name for N-Phenylacetyl-L-prolylglycine ethyl ester, a powerful nootropic that often draws comparisons to Piracetam due to its similar benefits on the brain. What many don’t realize is that Noopept was actually designed to be an upgraded version of Piracetam since Piracetam requires high doses and its effectiveness is limited on various populations of people.

Developed in 1996, Noopept is up to 1000 times more potent that Piracetram. The effects of Noopept are similar to Piracetam in that they are both water-soluble and enhance cognition. They also both are able to improve memory, help with problem solving, and repair damage to the brain. They help create proteins that your brain requires for growing and healing neurons.

The difference between the two nootropics is that Noopept also can help with memory retention and recall. In addition to its cognitive enhancements, Noopept also can positively affect anxiety and has anti oxidant elements as well. This is due to the fact that Noopept turns to cyclprolylglycine (CPG), a natural occurring chemical in the brain that affects mental wellness.

However, while Piracetam is a descendant of the Racetam family, Noopept has a different chemical structure and is not technically considered a Racetam.

With that being said, the biggest difference between the two nootropics is that Noopept is much more potent than Piracetam and fairly cheap, making it one of the most popular nootropics for neurohackers [1].

What is the proper Noopept dosage?

If you’re wondering how much noopept to take, the most commonly recommended oral dose of Noopept is 10-30mg per day. To get to this daily total, typically a dose of 5-15mg is taken twice a day.

Keep in mind that if you decide to take Noopept before bed, you may experience vivid dreams or experience difficulty falling asleep so its usually consumed after a regular meal.

How to take Noopept

It is recommended that you only take noopept on a 1.5 to 3 month cycle. After taking Noopept for 3 months, stop use for a minimum of 1 month then repeat the 1.5 to 3 month cycle. This will help to prevent user from forming a Noopept tolerance.

Noopept capsules

The standard Noopept dose is 10mg, consumed two times per day, each after a meal. However, if this isn’t providing the desired effects, up to 30mg for your daily total can be consumed.

Some have reported taking Noopept sublingual, meaning taking it under the tongue in order to get the substance in to the bloodstream more quickly. This is typically done by taking a pill and letting it sit under the tongue until it dissolves.

We do not recommend doing this. There isn’t much point it taking Noopept under the tongue to speed up its effectiveness because Noopept is already one of the fastest acting nootropics out there.

People usually feel effects within approximately 10-15 minutes of ingestion. If you do decide to take Noopept sublingually, it is highly recommended that you first consult a physician.

Noopept powder

Noopept powder has the same standard dose of 10mg, consumed twice per day. Like the capsules it is recommended that you consume the powder after a meal. Up to 30 mg (for your daily total) can be consumed in order to achieve your desired results.

In order to make Noopept safety a main priority, please keep in mind that snorting noopept is not how noopept powder is meant to be consumed and may cause serious side effects. Do NOT snort noopept powder, it can be very dangerous.

Noopept nasal spray

The Noopept spray requires a smaller daily dose (3mg). This is roughly the equivalent of 13mg of Noopept when consumed orally. Each nasal spray is approximately 1.5mg so it requires 2 sprays to hit your approximate daily dose.

However, before using the Noopept nasal spray it is important to know that Noopept was not created to be ingested in this manner so please use at your own risk.

Noopept side effects

Typically if a user consistently consumes the recommended dose of 10-30mg of Noopept per day, most people will not experience adverse side effects. However, side effects have been reported.

Unfortunately Noopept hasn’t been well-studied and therefore doesn’t provide sufficient data to adequately provide all the various side effects a user might experience. Because of this, it is highly recommended that you consult with your physician before taking Noopept.

With that being side, some of the side effects of Noopept that have been reported. Users have reported experiencing the following symptoms:

  • Anxiety
  • Increased or decreased appetite
  • Depression
  • Irritability
  • Restlessness
  • Insomnia
  • Headaches
  • Dizziness
  • Fatigue
  • Unable to think clearly

Another important thing to note regarding Noopept is that some users have reported a significant crash in cognitive performance when used for an extended period of time. This means that while Noopept provides great short-term cognitive effects, taking Noopept a long time can actually make you less productive then you were before consuming Noopept.

Users have also reported that stacking a Choline supplement with Noopept has helped eliminate or alleviate painful headaches while taking Noopept.

Is Noopept Safe?

It is highly recommended that you consult with a physician before consuming Noopept. It is possible that Noopept conflicts with your current prescriptions, causing adverse side effects.

In addition, Noopept’s mechanism of action isn’t fully understood and sufficient studies have not been conducted for the effects of Noopept on the brain long-term.

With that being said, if you take the recommended dosage most people have not reported experiencing adverse side effects. However, we recommend that you first read the list of side effects (listed above) in order to make a educated decision about whether or not you want to give Noopept a try. Please note that this isn’t a complete comprehensive list.

Noopept benefits

Before stating these benefits, it is important to be aware that while Noopept may provide some benefits in the short-term, people have actually reported a cognitive decline in the long-term. Make sure you have done your research before taking Noopept.

Some reported benefits of Noopept include:

  • Improved memory – Noopept improves alpha brain wave function which in turn, improves memory function.
  • Enhanced mental clarity – Noopept studies have shown that the nootropic can help make the neuron receptors more sensitive and reactive.
  • Reduced stress levels – Benzodiazepine receptors in the hippocampus correspond directly to your stress levels. Noopept can affect the hippocampus in order to reduce stress.
  • Boosted Focus – While studies are limited, improved focus can most likely linked to the regulation of acetylcholine and brain waves.
  • May help with Alzheimer’s – Studies are lacking but Noopept hase been claimed to help protect neurons and prevent cell death which happens to be one of the main causes of Alzehimer’s.

The best Noopept stack

Here are a few of the most common Noopept stacks that individuals have reported using and experienced a positive result. From our research we have that these 3 stacks seem to be synergistic and often help reduce or eliminate adverse side effects while maximizing results.

Noopept, Alpha GPC, and Piracetam

One of the issues that people have reported with taking Noopept is that they experience painful headaches. One of the main reasons we included Alpha GPC in this stack is to help remove those headaches while also improving the effectiveness of Piracetam.

In addition, Piracetam helps aid Acetycholine neurotransmitters in the brain while Noopept works on the Glutamate neurotransmitter. The combination of this results in better memory, problem solving, and overall cognitive function and ability.

Noopept and Choline

Noopept works by primarily helping the Glutamate neurotransmitter. In contrast, Choline primarily helps the Acetycholine neurotransmitter which is critical for memory function.

Choline is one of the most common supplements in nootropic stacks because it is an essential ingredient for protecting the cell membranes. Since the vast majority of people have a Choline deficiency, this can go a long way in improving mood, concentration, and memory for most people.

In addition, Choline also seems to help reduce or eliminate headaches caused by taking Noopept.

Noopept and Aniracetam

While both Noopept and Aniracetam work similarly, they also are synergistic. Noopept is excellent for increasing memory and works almost immediately.

Aniracetam is a nootropic from the racetam family. Like Noopept, it is great for improving learning and memory but also is known to improve mood by reducing anxiety.

Noopept FAQs

How long does Noopept last?

Research has found that the amount of time Noopept lasts will vary slightly. The Noopept half life ranges between 30 – 60 minutes and in some cases, an even shorter amount of time. For those of you unfamiliar with the term half-life, this is the amount of time that the substance takes in the body to be eliminated by half.

When some people learn that the half-life of Noopept is very short, they are discouraged from giving Noopept a try. While we don’t recommend trying Noopept due to safety reasons, this shouldn’t be the reason you decide not to try it.

Just because Noopept has a very short half life doesn’t mean that after 30-60 minutes Noopept it is only 50% as effective. It simply means that the body has absorbed and eliminated half of the Noopept dosage in the blood stream. However, the effects of Noopept can be experienced for long after the body has absorbed it.

Does Noopept work?

Yes, Noopept does work. Due to its quick short-term results, Noopept has become one of the most popular nootropics in the world. Noopept helps to improve alpha wave functionality within the brain. When alpha brain waves are heightened, it becomes easier to commit things to memory and recall memories later. It also helps the brain with problem solving.

This stimulant won’t feel as drastic a change as drinking a cup of coffee, but you will also not get the jitters and heightened anxiety that is usually associated with high amounts of caffeine.

Will Noopept get you high?

No, Noopept will not get you high. Unlike many stimulants such as Adderall, Noopept will only provide you with a mild lift in focus and overall ability to think. This boost won’t be as strong as drinking a cup of coffee (which contains 200mg of caffeine on average), but unlike caffeine you won’t feel overstimulated, fidgety, and anxious.

However, Noopept isn’t as subtle as many nootropics that take multiple weeks before feeling the effects. You should feel the effects of Noopept within 10-15 minutes of consumption which is one of the main reasons why it is so popular. Both students and work professionals want an instant brain booster.

Is Noopept Legal in the United States?

Yes, Noopept is legal in the United States and is readily available for purchase online and in stores. While Noopept isn’t a controlled substance in the United States, this doesn’t mean it is necessarily safe to consume. According to the FDA, Noopept is an unapproved drug. Therefore, make sure to do your research before consuming Noopept.

Is Noopept a good supplement for anxiety?

Yes, Noopept has been reported to reduce feeling of anxiety. It affects the hippocampus to relieve stress. However, this shouldn’t be used as an alternative to taking prescription medication for anxiety. Always consult a physician before taking a supplement that may conflict with medications you are already taking.

Noopept review

Noopept is both a cheap and fairly effective nootropic short-term. This is one of the reasons that Noopept has become so popular since its creation in 1996. However, its effectiveness (short-term) is not all that matters when looking at a Nootropic.

The biggest concern that we have with Noopept is the lack of studies to confirm its safety long-term. While we know that it is a very effective brain performance booster in the short-term, some people have reported a cognitive decline when consuming Noopept over a long duration.

With that in mind, there just isn’t enough information for us to comfortably recommend using Noopept. Until more research is done, it just isn’t worth the risk.

Where to buy Noopept?

If you’re looking for where to buy Noopept in store, you can find it at places like GNC or other local supplement shops. For those who are looking to buy Noopept online, you can purchase Noopept on Amazon, Nootropics Depot, and many other online vendors.

However, we do NOT recommend buying Noopept based on our research. Unfortunately, there are insufficient studies on Noopept to confirm whether or not it is safe to consume long-term. Some individuals have reported cognitive decline when consuming Noopept for an extended period of time. Until further studies have occurred, we highly recommend you stick to a safe and proven nootropic.

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Greg Don wearing sunglasses

Greg Don


Greg Don is the main author of Zimmez. He’s also an avid health and fitness enthusiast. He enjoys spending time outdoors fishing, hiking,, and playing tennis. You can find more about him here.

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